Table 3 Associations between the TAP1 genotype and CRC when stratified by smoking status
Smoking status | Genotype | Controls | Cases | Crude OR (95 % CI) | Adjusted OR (95 % CI) |
|---|---|---|---|---|---|
Never | C/C (%) | 51 (45.5) | 24 (31.6) | – | – |
C/T (%) | 53 (47.3) | 45 (59.2) | 1.80 (0.97–3.36) | 1.94 (1.02–3.75)* | |
T/T (%) | 8 (7.14) | 7 (9.21) | 1.86 (0.62–5.55) | 2.04 (0.62–6.58) | |
Total | 112 | 76 | |||
C/T + T/T (%) | 61 (54.5) | 52 (68.4) | 1.81 (0.99–3.32) | 1.95 (1.05–3.72)* | |
Smoker | C/C (%) | 55 (42.0) | 14 (20.9) | – | – |
C/T (%) | 62 (47.3) | 46 (68.7) | 2.91 (1.46–5.82)** | 2.84 (1.43–5.92)** | |
T/T (%) | 14 (10.7) | 7 (10.4) | 1.96 (0.68–5.64) | 1.98 (0.64–5.83) | |
Total | 131 | 67 | |||
C/T + T/T (%) | 76 (58.0) | 53 (79.1) | 2.74 (1.39–5.38)** | 2.69 (1.37–5.51)** |