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Table 4 Urinary levels of di(2-ethylhexyl)phthalate metabolites in mice and a general population of humans, and total amount of excretion of these metabolites

From: Species and inter-individual differences in metabolic capacity of di(2-ethylhexyl)phthalate (DEHP) between human and mouse livers

Urinary metabolitesa

Human

Mouse

Mean

Median

Mean

Median

MEHP

2.3

2.1

132.2

162

Phthalic acid and 2cx-MMHP

N.I.

N.I.

2557.3

2502

5oxo-MEHP

14.4

15.9

8.3

2.5

5cx-MEPP

34.5

35.3

<5

<5

5OH-MEHP

21.8

23.1

N.I.

N.I.

Sum (µmol/l urine)b

0.24

 

8.8

 
  1. Data on human urine were obtained from Colacino et al. [24] using samples of the 2003–2004 U.S. National Health and Nutrition Examination Survey [1]
  2. The values of mice were determined by duplicate analyses
  3. MEHP mono(2-ethylhexyl)phthalate, 2cx-MMHP mono(2-carboxymethylhexyl)phthalate, 5oxo-MEHP mono(2-ethyl-5-oxo-hexyl)phthalate, 5cx-MEPP mono(2-ethyl-5-carboxypentyl)phthalate, 5OH-MEHP mono(2-ethyl-5-hydroxyhexyl)phthalate
  4. aData on urinary levels of metabolites are presented as the geometric mean and median in humans and mice (units: ng/ml urine)
  5. bTotal amount of excretion (Sum) of these di(2-ethylhexyl)phthalate (DEHP) metabolites
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Environmental Health and Preventive Medicine

ISSN: 1347-4715

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