Skip to main content

Table 6 Gender differences in the effect of PCB/dioxins exposure on the onset of otitis media at 18 months of age in multiple logistic regression models

From: Ten years of progress in the Hokkaido birth cohort study on environment and children’s health: cohort profile—updated 2013

(log10 transformed)

 

Adjusted

p-value for trend

 

Quartile 2

Quartile 3

Quartile 4

 
 

OR (95 % CI)

OR (95 % CI)

OR (95 % CI)

 

All

     

 TEQ†

     

  PCDDs

∑ PCDDs

1.2 (0.53–2.7)

1.1 (0.50–2.6)

1.5 (0.65–3.5)

0.39

  PCDFs

∑ PCDFs

1.6 (0.68–3.8)

2.2 (0.93–5.1)

2.5 (1.1–5.9)*

0.03

  Non-ortho PCBs

∑ Non-ortho PCBs

1.8 (0.79–4.2)

2.5 (1.1–6.0)*

1.5 (0.62–3.6)

0.30

  Total Dioxins

 

2.1 (0.92–4.8)

1.7 (0.71–3.9)

1.7 (0.70–4.1)

0.38

 Congeners

     

  PCDDs

OCDD

3.4 (1.4–8.5)*

2.8 (1.1–7.0)*

2.6 (1.0–6.9)*

0.12

  PCDFs

2,3,4,7,8-PeCDF

1.6 (0.7–3.9)

2.0 (0.88–4.8)

2.8 (1.2–6.6)*

0.02

  Non-ortho PCBs

33′44′-TCB(#77)

2.4 (0.99–5.9)

1.4 (0.61–3.3)

3.4 (1.6–7.3)*

0.01

  Mono-ortho PCBs

233′44′5′-HxCB(#157)

2.4 (1.0–5.5)*

1.1 (0.43–2.7)

2.5 (1.1–5.9)*

0.16

Males

     

 TEQ†

     

  PCDDs

∑ PCDDs

0.5 (0.13–1.8)

2.0 (0.65–6.2)

2.9 (0.83–10)

0.03

  PCDFs

∑ PCDFs†

1.0 (0.28–3.3)

2.9 (0.87–9.8)

3.8 (1.1–13)*

0.01

  Non-ortho PCBs

∑ Non-ortho PCBs

2.4 (0.70–8.3)

2.9 (0.86–9.7)

3.6 (0.98–13.3)

0.05

  Total dioxins

 

2.1 (0.61–6.9)

2.2 (0.67–7.1)

4.4 (1.2–16)*

0.03

 Congeners

     

  PCDFs

2,3,4,7,8-PeCDF

1.7 (0.48–6.0)

2.9 (0.87–10)

5.3 (1.5–19)*

0.01

  Non-ortho PCBs

33′44′-TCB(#77)

2.8 (0.85–9.4)

0.9 (0.24–3.4)

3.5 (1.2–11)*

0.08

33′44′55′-HxCB(#169)

1.0 (0.25–3.8)

3.0 (0.93–9.6)

3.6 (1.1–12)*

0.01

  Mono-ortho PCBs

2344′5-PeCB(#114)

2.4 (0.62–8.9)

4.5 (1.2–16.6)*

4.9 (1.3–18)*

0.01

23′44′55′-HxCB(#167)

3.1 (0.83–11)

3.3 (0.91–11)

3.7 (1.0–13)*

0.06

233′44′5′-HxCB(#157)

4.5 (1.2–17)*

1.6 (0.37–6.5)

7.5 (1.9–29)*

0.02

Female

     

 TEQ†

     

  PCDDs

∑ PCDDs

2.3 (0.71–7.6)

0.5 (0.11–2.0)

1.1 (0.30–4.1)

0.44

  PCDFs

∑ PCDFs

4.0 (1.1–14.7)*

1.2 (0.30–5.1)

1.3 (0.29–5.8)

0.41

  Non-ortho PCBs

∑ Non-ortho PCBs

1.3 (0.41–4.3)

1.9 (0.51–7.1)

0.8 (0.22–3.1)

0.86

  Total Dioxins

 

2.6 (0.78–8.6)

1.0 (0.25–4.0)

1.0 (0.27–4.1)

0.57

 Congeners

  Non-ortho PCBs

33′44′-TCB(#77)

1.4 (0.3–6.9)

1.5 (0.45–4.9)

3.8 (1.2–12)*

0.03

  1. This table was reconstructed by using data from a previously published study by Miyashita et al. [62]. Only statistically significant congeners are presented in this table. (* p < 0.05). The OR (95 % CI) versus the first quartile (reference) in the logistic regression model was adjusted for maternal educational level, parity, infant gender, duration of breast-feeding, environmental tobacco exposure, day care attendance and blood sampling period (infant gender was excluded from covariates in gender-stratified analysis)
  2. aquartiles applied as ordinal variables in the model
  3. p < 0.05, ** p < 0.01; Statistically significant, p-value
  4. The TEQ levels were calculated by multiplying the levels of individual congeners by its TEF values of WHO 2005 [38]