Ten years of progress in the Hokkaido birth cohort study on environment and children’s health: cohort profile—updated 2013

Kishi, Reiko; Kobayashi, Sachiko; Ikeno, Tamiko; Araki, Atsuko; Miyashita, Chihiro; Itoh, Sachiko; Sasaki, Seiko; Okada, Emiko; Kobayashi, Sumitaka; Kashino, Ikuko; Itoh, Kumiko; Nakajima, Sonomi

doi:10.1007/s12199-013-0357-3

Environmental Health and Preventive Medicine

Table 5 Gender differences in the effect of PCB/dioxins exposure on cord blood IgE level in multiple linear regression models

From: Ten years of progress in the Hokkaido birth cohort study on environment and children’s health: cohort profile—updated 2013

(log₁₀ transformed)	Male (n = 112)				Female (n = 123)
	Crude model		Adjusted model		Crude model		Adjusted model
	β (95 % CI)	p value	β (95 % CI)	p value	β (95 % CI)	p value	β (95 % CI)	p value
Total
Total PCDD	0.032 (−0.681, 0.746)	0.928	−0.061 (−0.821, 0.700)	0.875	0.562 (−0.164, 1.287)	0.128	0.594 (−0.198, 1.386)	0.140
Total PCDF	−0.630 (−1.503, 0.244)	0.156	−1.097 (−2.127, −0.067)	0.037**	0.455 (−0.350, 1.261)	0.265	0.590 (−0.313, 1.493)	0.198
Total PCDD/PCDF	0.012 (−0.715, 0.740)	0.973	−0.088 (−0.866, 0.689)	0.822	0.571 (−0.164, 1.306)	0.127	0.607 (−0.195, 1.410)	0.136
Total non-ortho PCBs	−0.201 (−0.811, 0.410)	0.516	−0.587 (−1.305, 0.132)	0.108	0.383 (−0.154, 0.919)	0.16	0.479 (−0.110, 1.067)	0.110
Total mono-ortho PCBs	−0.252 (−0.804, 0.299)	0.367	−0.482 (−1.137, 0.172)	0.147	0.120 (−0.366, 0.605)	0.626	0.230 (−0.330, 0.790)	0.418
Total DL-PCB	−0.253 (−0.805, 0.300)	0.367	−0.484 (−1.140, 0.171)	0.146	0.121 (−0.365, 0.607)	0.622	0.232 (−0.329, 0.792)	0.415
Total dioxins	−0.246 (−0.817, 0.325)	0.395	−0.521 (−1.275, 0.234)	0.174	0.142 (−0.346, 0.631)	0.566	0.375 (−0.219, 0.970)	0.214
TEQ (WHO 2005)^†
Total PCDD TEQ	−0.630 (−1.288, 0.028)	0.060*	−1.008 (−1.822, −0.194)	0.016**	0.138 (−0.453, 0.728)	0.645	0.332 (−0.376, 1.039)	0.355
Total PCDF TEQ	−0.689 (−1.408, 0.030)	0.060*	−1.229 (−2.113, −0.344)	0.007***	0.390 (−0.227, 1.007)	0.213	0.643 (−0.065, 1.352)	0.075
Total PCDD/PCDF TEQ	−0.681 (−1.373, 0.011)	0.054*	−1.144 (−2.006, −0.282)	0.010**	0.203 (−0.406, 0.812)	0.511	0.427 (−0.299, 1.153)	0.246
Total non-ortho PCBs TEQ	−0.234 (−0.689, 0.222)	0.312	−0.498 (−1.017, 0.021)	0.060*	0.205 (−0.216, 0.627)	0.337	0.251 (−0.217, 0.719)	0.290
Total mono-ortho PCBs TEQ	−0.252 (−0.804, 0.299)	0.367	−0.482 (−1.137, 0.172)	0.147	0.120 (−0.366, 0.605)	0.626	0.230 (−0.330, 0.790)	0.418
Total DL-PCB TEQ	−0.242 (−0.708, 0.224)	0.305	−0.514 (−1.047, 0.019)	0.058*	0.202 (−0.228, 0.632)	0.354	0.254 (−0.224, 0.732)	0.295
Total dioxins TEQ	−0.535 (−1.176, 0.106)	0.101	−1.011 (−1.794, −0.229)	0.012**	0.234 (−0.337, 0.806)	0.419	0.406 (−0.265, 1.076)	0.233

This table was reconstructed by using data from a previously published study by Washino et al. [61]. Multiple linear regression adjusted for mother’s age, maternal allergy history, paternal allergy history, smoking during pregnancy, parity, gestational age, frequency of deep sea fish consumption, distance of highway to home and blood sampling period
* p < 0.10, ** p < 0.05, *** p < 0.01
^†The TEQ levels were calculated by multiplying the levels of individual congeners by their TEF values of WHO 2005 [38]

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