Ten years of progress in the Hokkaido birth cohort study on environment and children’s health: cohort profile—updated 2013

Kishi, Reiko; Kobayashi, Sachiko; Ikeno, Tamiko; Araki, Atsuko; Miyashita, Chihiro; Itoh, Sachiko; Sasaki, Seiko; Okada, Emiko; Kobayashi, Sumitaka; Kashino, Ikuko; Itoh, Kumiko; Nakajima, Sonomi

doi:10.1007/s12199-013-0357-3

Environmental Health and Preventive Medicine

Table 4 Gender differences in the effect of PCB/dioxins exposure on BSID-II Mental (MDI) and Psychomotor (PDI) development scores at 6 months of age in multiple linear regression models

From: Ten years of progress in the Hokkaido birth cohort study on environment and children’s health: cohort profile—updated 2013

(log₁₀ transformed)	6 months MDI						6 months PDI
	Male (n = 99)			Female (n = 91)			Male (n = 99)			Female (n = 91)
	β ^a	t	p value	β ^a	t	p value	β ^a	t	p value	β ^a	t	p value
PCDD
2,3,7,8-TCDD	−0.15	−1.54	0.13	−0.05	−0.48	0.63	−0.19	−2.01	0.048*	−0.06	−0.56	0.58
1,2,3,7,8-PeCDD	−0.07	−0.70	0.48	0.22	2.14	0.04*	−0.10	−0.98	0.33	−0.04	−0.33	0.75
1,2,3,4,6,7,8-HpCDD	−0.25	−2.52	0.01*	−0.14	−1.34	0.18	−0.24	−2.56	0.01*	−0.19	−1.78	0.08
OCDD	−0.09	−0.92	0.36	−0.18	−1.74	0.09	−0.22	−2.33	0.02*	−0.21	−1.97	0.05
PCDF
2,3,7,8-TCDF	−0.08	−0.84	0.41	−0.11	−1.05	0.30	−0.21	−2.21	0.03*	−0.13	−1.21	0.23
1,2,3,7,8-PeCDF	−0.02	−0.22	0.83	−0.06	−0.54	0.59	−0.22	−2.38	0.02*	−0.17	−1.59	0.12
1,2,3,4,7,8-HxCDF	−0.07	−0.73	0.47	−0.10	−0.93	0.36	−0.17	−1.69	0.09	−0.25	−2.36	0.02*
Non-ortho PCB
33′44′5-PenCB (#126)	−0.03	−0.33	0.74	−0.01	−0.10	0.93	−0.15	−1.62	0.11	−0.24	−2.25	0.03*
Mono-ortho PCB
2344′5-PeCB (#114)	−0.07	−0.71	0.48	0.08	0.79	0.43	−0.19	−2.00	0.049*	−0.16	−1.49	0.14
2′344′5-PeCB (#123)	0.02	0.23	0.82	0.01	0.05	0.96	−0.13	−1.39	0.17	−0.25	−2.37	0.02*
233′44′5′-HxCB (#157)	−0.08	−0.85	0.40	0.10	0.90	0.37	−0.21	−2.19	0.03*	−0.11	−1.09	0.28
23′44′55′-HxCB (#167)	−0.05	−0.49	0.63	0.04	0.41	0.69	−0.22	−2.35	0.02*	−0.15	−1.38	0.17
Di-ortho PCB
22′33′44′5-HpCB(#170)	−0.13	−1.25	0.22	0.10	0.88	0.38	−0.25	−2.47	0.02*	−0.04	−0.37	0.71
22′344′55′-HpCB(#180)	−0.13	−1.23	0.22	0.10	0.88	0.38	−0.24	−2.42	0.02*	0.00	0.01	1.00
Total
Total PCDD	−0.10	−1.00	0.32	−0.17	−1.63	0.11	−0.22	−2.31	0.02*	−0.21	−1.97	0.05
Total PCDF	−0.06	−0.61	0.55	0.02	0.15	0.88	−0.18	−1.81	0.07	−0.20	−1.83	0.07
Total PCDD/PCDF	−0.10	−1.00	0.32	−0.17	−1.58	0.12	−0.22	−2.33	0.02*	−0.21	−1.98	0.05
Total non-ortho PCBs	−0.01	−0.12	0.91	0.03	0.25	0.81	−0.16	−1.72	0.09	−0.19	−1.73	0.09
Total mono-ortho PCBs	−0.05	−0.55	0.58	0.05	0.46	0.64	−0.19	−1.97	0.05	−0.17	−1.60	0.11
Total DL-PCB	−0.05	−0.55	0.59	0.05	0.46	0.65	−0.19	−1.97	0.05	−0.17	−1.60	0.11
Total dioxins	−0.06	−0.56	0.58	0.04	0.39	0.70	−0.19	−2.03	0.045*	−0.17	−1.65	0.10
Total PCDD-TEQ^†	−0.09	−0.87	0.39	0.14	1.31	0.19	−0.12	−1.24	0.22	−0.08	−0.77	0.44
Total PCDF-TEQ^†	−0.03	−0.28	0.78	0.08	0.73	0.47	−0.17	−1.74	0.09	−0.15	−1.42	0.16
Total PCDD/PCDF-TEQ^†	−0.08	−0.75	0.45	0.13	1.19	0.24	−0.14	−1.39	0.17	−0.10	−0.95	0.34
Total non-ortho PCBs-TEQ^†	−0.03	−0.28	0.78	0.01	0.08	0.94	−0.16	−1.67	0.10	−0.22	−2.04	0.04*
Total mono-ortho PCBs-TEQ^†	−0.05	−0.55	0.58	0.05	0.46	0.64	−0.19	−1.97	0.05	−0.17	−1.60	0.11
Total DL-PCB-TEQ^†	−0.05	−0.55	0.59	0.05	0.46	0.65	−0.19	−1.97	0.05	−0.17	−1.60	0.11
Total dioxins-TEQ^†	−0.05	−0.53	0.60	0.09	0.84	0.41	−0.15	−1.52	0.13	−0.15	−1.39	0.17

This table was constructed by reanalyzing the data from a previous study by Nakajima et al. [60]. Only statistically significant congeners are presented in this table (*p < 0.05)
^†The TEQ levels were calculated by multiplying the levels of individual congeners by its TEF values of WHO 2005 [38]

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