Ten years of progress in the Hokkaido birth cohort study on environment and children’s health: cohort profile—updated 2013

Table 2 Genetic factors and its environmental interaction being studied in the Hokkaido study (up to 2013)

Maternal genetic factors	Environmental exposure	Outcomes	Results	Ref.
AHR, AHRR, CYP1A1, CYP1A2, CYP1B1	Dioxin and dioxin-like PCBs	(Concentration)	Decreased	[55]
AHR, CYP1A1, GSTM1, GSTT1	Active tobacco smoking (PAHs)	Birth size	Reduction	[56]
NQO1, CYP2E1, MGMT	Active tobacco smoking	Birth size	Reduction	[57]
5,10-MTHFR (C677T, A1298C)	Tobacco smoking and Folic acid	Birth weight	Reduction	[58]

Genes described in bold font in the table represent the genetic polymorphisms that are significantly associated with the outcome
AHR aryl hydrocarbon receptor, AHRR AHR repressor, CYP1 cytochrome P450, family 1, CYP1A1 CYP1 subfamily A polypeptide 1, CYP1A2 CYP1 subfamily A polypeptide 2, CYP1B1 CYP1 subfamily B polypeptide 1, GSTM1 glutathione-S-transferase mu-1, GSTT1 glutathione-S-transferase theta-1, NQO1 NAD(P)H: quinone oxidoreductase 1, CYP2E1 CYP2 subfamily E polypeptide 1, MTHFR methylenetetrahydrofolate reductase

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