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Table 1 Model parameters

From: An emission model tracking the life cycle pathways of human pharmaceuticals in Korea

Name

Description

Value or equation

AR.inpt

Administration rate of inpatient (%)

100a

AR.outpt

Administration rate of outpatient (%)

39.1–100.0b

BR.stp

Biodegradation rate in sewage treatment plant (%)

Pharmaceutical specific value

DISR.hospital

Disuse inventory ratio in hospitals (%)

0.0–10.0c

DISR.pharmacy

Disuse inventory ratio in pharmacies (%)

0.0–10.0c

DISR.ts

Disuse inventory ratio in total supplies (%)

0.0–10.0c

DISR.wholesaler

Disuse inventory ratio in wholesalers (%)

0.0–10.0c

ER

Excretion rate (%)

Pharmaceutical specific value

INCN.in

Inflow of pharmaceuticals to incineration plant (kg/year)

DIS.ts + DIS.w + DIS.h + DIS.p + TB

LEACH.in

Inflow of pharmaceuticals to leachate treatment plant (kg/year)

W.wb + RE.incn·LFR.incn/100

LFR.incn

Landfill rate out of incineration residue (%)

0.0d

LR.sept_niso

Linked treatment rate of septic tank to nighsoil treatment plant (%)

73.6e

NISO.in

Inflow of pharmaceuticals to nightsoil treatment plant (kg/year)

SEPT.in·LR.sept_niso/100

NS

Net supply (kg/year)

TS-DIS.ts

RR.incn

Removal rate in incineration plant (%)

100f

SEPT.in

Inflow of pharmaceuticals to septic tank (kg/year)

TA.excretion + W.toilet

SL.tot

Total residue in sludge from water treatment plants (kg/year)

SL.stp + SL.leach + SL.niso

SLR.stp

Removal rate by sludge separation in sewage treatment plant (%)

Pharmaceutical specific value

SR.hospital

Supply rate to hospital (%)

25.5g

SR.pharmacy

Supply rate to pharmacy (%)

18.1g

STP.in

Inflow of pharmaceuticals to sewage treatment plant (kg/year)

W.sink + L.setp_stp + L.niso_stp + L.incn_stp

TA.imp

Total amount of import (kg/year)

Pharmaceutical specific value

TA.prod

Total amount of production (kg/year)

Pharmaceutical specific value

TB

Returned amount in Take-back program (kg/year)

TA.waste·TBR/100

TBR

Return rate to Take-back program (%)

0–100

TE.water

Total emission to surface water (kg/year)

E.stp + E.leach

TS

Total supply to region (kg/year)

TA.prod + TA.imp

WR.sink

Waste rate into sink (%)

(100 − TBR)·0.07h

WR.toilet

Waste rate into toilet (%)

(100 − TBR)·0.07h

WR.wb

Waste rate into waste bin (%)

(100 − TBR)·0.86h

  1. aInpatients are hardly allowed to waste prescribed medications
  2. bThe minimum value of 39.1 % for AR.outpt was taken from the rate of people who take all the medications they purchase in a survey performed in 2009 [26]
  3. cAccording to a survey performed in 2009 [30], these rates were reported to be <10 %
  4. dAssumed to be negligible
  5. e2009 data from Sewerage of Korea statistics [29]
  6. fAssumed to be complete
  7. g2009 data from Korean pharmaceutical industry statistics [28]
  8. hThe ratio of 86:7:7 was taken from a survey in 2009 [26]