Fig. 5
From: In vivo modulation of iNOS pathway in hepatocellular carcinoma by Nigella sativa
Histological examination of the livers of animals in all groups. a–d Representative photomicrographs of livers of normal control rats (a), NSEE control rats (b), cancer control rats (c), and NSEE-DENA rats (d). Hematoxylin and eosin staining revealed normal architecture and normal cells with granulated cytoplasm and uniform nuclei in liver sections of normal control and NSEE control rats. Loss of normal architecture, enlargement of sinusoids, and irregularly shaped neoplastic hepatocytes with polymorphic and hyperchromatic nuclei were observed in liver sections of cancer control rats (arrows), while these changes were reduced in NSEE-DENA rats with few neoplastic hepatocytes. Magnification ×200