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Table 3 Historical review of reference values for WBC counts in healthy Japanese

From: Reference value and annual trend of white blood cell counts among adult Japanese population

Authors

Years

Ref.

Sex (M for men, W for women)

WBC counts (cells/mm3)

Notes

AM

ASD

Min.

Max.

Masai

1914

[14]

M

7,473

 

4,220

12,600

Healthy medical students

Kura

1925

[15]

M

7,718

 

4,200

12,900

Healthy army soldiers

Kitajima

1928

[9]

M + W

5,981–7,827a

 

4,200

12,437

Healthy men and women of various occupations aged 20–60 years

Komiya

1938

[6]

   

4,000

10,000

Statement in a textbook

  

[6]

   

6,000

8,000

 

Miyazu

1943

[10]

M + W

6,652–7,295a

 

4,700

13,800

Healthy subjects

Asai et al.

1974

[11]

M

6,000–7,000b

 

<4,000

>11,000

Citation of the study by Hibino which was conducted in 1954–1955

Miyasaka

1957

[12]

M

6,616–6,933

 

4,000

10,000

 

1957

[12]

W

6,545–6,870

 

3,500

9,000

 

Maekawa and Kinugasa

1957

[16]

M + W

6,480

1,110

  

≤60 years

1957

[16]

M + W

6,680

110

  

18–30 years

Inoue et al.

1959

[17]

M

6,314

1,375

2,550–3,000

13,350–13,800

Adult healthy workers; min. and max. values are shown by ranges

1959

[17]

W

6,286

1,465

2,550–3,000

12,000–12,450

Adult healthy workers; min. and max. values are shown by ranges

Shirakura et al.

1978

[18]

M

6,949

1,632

   

1978

[18]

W

6,756

1,852

   

Goto et al.

1993

[13]

M

6,080–6,380

 

3,400

9,190

 

1993

[13]

W

5,500–5,650

 

3,270

7,930

 

Okabe

1995

[19]

M

7,500

1,400

  

Up to 59 years

1995

[19]

W

7,600

1,100

  

Up to 59 years

Shiga et al.

1999

[20]

M + W

6,800

 

2,900

10,700

Minimum and maximum values reported for each of decades of years of age (20–69 years)

Hasegawa et al.

2002

[21]

M + W

5,795

1,521

  

See footnote c

Tatsukawa et al.

2008

[22]

M

6,700

1,700

   

2008

[22]

W

6,000

1,600

   

The present study

2002

 

M

6,248

1,751

  

20–60-year-old men (for details, see Table 1)

2002

 

M (never smokers)

5,609

1,373

  

20–60-year-old never-smoking men (for details, see Table 1)

2010

 

M

6,162

1,719

  

20–60-year-old men (for details, see Table 1)

2010

 

M (never smokers)

5,666

1,412

  

20–60-year-old never-smoking men (for details, see Table 1)

  1. aVariation by decades of age, with no consistent age-dependent trends
  2. bThe range of modes for each of decades of years of age (20–59 years)
  3. cData on smokers and nonsmokers were combined by the present authors for a whole group