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Table 4 Odds ratios of bladder cancer patients for the NAT2 genotype combined with the CYP1A2, SULT1A1, and UGT2B7 genotypes

From: Association of genotypes of carcinogen-metabolizing enzymes and smoking status with bladder cancer in a Japanese population

Genotype

NAT2 rapid or intermediate

NAT2 slow

ORa (95 % CI)

No.c

p value

ORa (95 % CI)

No.

p value

CYP1A2*1 C/*1A or *1A/*1A

1b

230/234

 

2.82 (1.42–5.60)

33/12

<0.01

CYP1A2 *1C/*1C

1.42 (0.65–3.15)

16/11

0.382

NC

3/0

NC

SULT1A1*1/*1

1b

190/192

 

3.18 (1.46–6.93)

28/9

<0.05

SULT1A1*2/*2 or *1/*2

1.06 (0.69–1.63)

56/53

0.791

2.72 (0.71–10.44)

8/3

0.145

UGT2B7 *1/*1

1b

120/129

 

2.85 (1.21–6.71)

21/8

<0.05

UGT2B7 *2/*2 or *1/*2

1.16 (0.82–1.66)

126/116

0.404

4.20 (1.34–13.14)

15/4

<0.05

  1. NC Not calculated due to the small number of control subjects
  2. aOdds ratios were adjusted for age and sex
  3. bReference category
  4. cNumber of patients/controls