Genotype | Non-smokers | Smokers | ||||
---|---|---|---|---|---|---|
Light smokers (≤37.4 pack-years) | Heavy smokers (>37.4 pack-years) | |||||
No.a Patient/control | ORb (95 % CI) | No.a Patient/control | ORb (95 % CI) | No.a Patient/control | ORb (95 % CI) | |
All | 85/81 | 1c | 94/99 | 0.89 (0.55–1.43) | 103/77 | 1.27 (0.76–2.13) |
CYP1A2 | ||||||
*1A/ *1C or *1A/ *1A | 81/78 | 1c | 87/96 | 0.86 (0.53–1.41) | 95/72 | 1.30 (0.76–2.21) |
*1C/ *1C | 4/3 | 1.16 (0.25–5.40) | 7/3 | 2.07 (0.50–8.58) | 8/5 | 1.47 (0.44–4.94) |
NAT2 | ||||||
Rapid or intermediate acetylator | 74/76 | 1c | 85/94 | 0.97 (0.59–1.61) | 87/75 | 1.31 (0.76–2.27) |
Slow acetylator | 11/5 | 2.07 (0.68–6.31) | 9/5 | 2.06 (0.62–6.87) | 16/2 | 8.57 (1.82–40.25)d |
SULT1A1 | ||||||
*1/ *1 | 63/62 | 1c | 70/82 | 0.86 (0.52–1.40) | 85/57 | 1.40 (0.81–2.42) |
*1/ *2 or *2/ *2 | 22/19 | 1.15 (0.56–2.35) | 24/17 | 1.30 (0.58–2.91) | 18/20 | 0.84 (0.37–1.94) |
UGT2B7 | ||||||
*1/ *1 | 38/41 | 1c | 51/59 | 0.87 (0.50–1.51) | 52/37 | 1.56 (0.83–2.95) |
*1/ *2 or *2/ *2 | 47/40 | 1.23 (0.66–2.27) | 43/40 | 1.29 (0.63–2.64) | 51/40 | 1.37 (0.64–2.95) |