Skip to main content

Table 3 Odds ratios of bladder cancer patients for the CYP1A2, NAT2, SULT1A1, and UGT2B7 genotypes stratified by smoking status

From: Association of genotypes of carcinogen-metabolizing enzymes and smoking status with bladder cancer in a Japanese population

Genotype

Non-smokers

Smokers

Light smokers (≤37.4 pack-years)

Heavy smokers (>37.4 pack-years)

No.a

Patient/control

ORb (95 % CI)

No.a

Patient/control

ORb (95 % CI)

No.a

Patient/control

ORb (95 % CI)

All

85/81

1c

94/99

0.89 (0.55–1.43)

103/77

1.27 (0.76–2.13)

CYP1A2

 *1A/ *1C or *1A/ *1A

81/78

1c

87/96

0.86 (0.53–1.41)

95/72

1.30 (0.76–2.21)

 *1C/ *1C

4/3

1.16 (0.25–5.40)

7/3

2.07 (0.50–8.58)

8/5

1.47 (0.44–4.94)

NAT2

 Rapid or intermediate acetylator

74/76

1c

85/94

0.97 (0.59–1.61)

87/75

1.31 (0.76–2.27)

 Slow acetylator

11/5

2.07 (0.68–6.31)

9/5

2.06 (0.62–6.87)

16/2

8.57 (1.82–40.25)d

SULT1A1

 *1/ *1

63/62

1c

70/82

0.86 (0.52–1.40)

85/57

1.40 (0.81–2.42)

 *1/ *2 or *2/ *2

22/19

1.15 (0.56–2.35)

24/17

1.30 (0.58–2.91)

18/20

0.84 (0.37–1.94)

UGT2B7

 *1/ *1

38/41

1c

51/59

0.87 (0.50–1.51)

52/37

1.56 (0.83–2.95)

 *1/ *2 or *2/ *2

47/40

1.23 (0.66–2.27)

43/40

1.29 (0.63–2.64)

51/40

1.37 (0.64–2.95)

  1. aNumber of patients/controls
  2. bOdds ratios were adjusted for age and gender
  3. cReference category
  4. d p value < 0.05