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Table 2 Serum level of alpha fetoprotein and activities of serum HK, GAPDH and G6PD in the experimental rat groups

From: Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma?

Parameter

Groups

1 (normal control)

2 (MENS control)

3 (premalignant group)

4 (premalignant treated group)

AFP (ng/ml)

4.04 ± 0.61

5.13 ± 0.33

61.06 ± 2.71###

17.9 ± 0.99***

HK (mU/ml)

5.7 ± 2.0

5.20 ± 2.6

9.84 ± 1. 65##

6.56 ± 2.61*

GAPDH (mU/ml)

25.3 ± 3.41

22.31 ± 5.12

33.16 ± 5.43##

24.12 ± 3.7**

G6PD (mU/ml)

0.50 ± 0.38

0.56 ± 0.32

2.4 ± 0.44###

1.75 ± 0.46*

  1. AFP, Alpha fetoprotein; HK, hexokinase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; G6PD, glucose-6-phosphate dehydrogenase
  2. Data are presented as the mean ± SD (n = 9 in each group)
  3. +MENS control group is compared to normal control, #premalignant group is compared to normal control, *premalignant treated group is compared to premalignant group (1 symbol = p < 0.05, 2 symbols = p < 0.01, 3 symbols = p < 0.001)