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Table 2 Serum level of alpha fetoprotein and activities of serum HK, GAPDH and G6PD in the experimental rat groups

From: Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma?

Parameter Groups
1 (normal control) 2 (MENS control) 3 (premalignant group) 4 (premalignant treated group)
AFP (ng/ml) 4.04 ± 0.61 5.13 ± 0.33 61.06 ± 2.71### 17.9 ± 0.99***
HK (mU/ml) 5.7 ± 2.0 5.20 ± 2.6 9.84 ± 1. 65## 6.56 ± 2.61*
GAPDH (mU/ml) 25.3 ± 3.41 22.31 ± 5.12 33.16 ± 5.43## 24.12 ± 3.7**
G6PD (mU/ml) 0.50 ± 0.38 0.56 ± 0.32 2.4 ± 0.44### 1.75 ± 0.46*
  1. AFP, Alpha fetoprotein; HK, hexokinase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; G6PD, glucose-6-phosphate dehydrogenase
  2. Data are presented as the mean ± SD (n = 9 in each group)
  3. +MENS control group is compared to normal control, #premalignant group is compared to normal control, *premalignant treated group is compared to premalignant group (1 symbol = p < 0.05, 2 symbols = p < 0.01, 3 symbols = p < 0.001)