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Fig. 4 | Environmental Health and Preventive Medicine

Fig. 4

From: Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat

Fig. 4

Effects of HFC-diet treatment on hepatic transforming growth factor-β1 (TGF-β1), platelet-derived growth factor-B (PDGF-B), α-smooth muscle actin (α-SMA) and α1 type I collagen protein and mRNA expressions. a Western blot results of respective protein expressions in whole liver tissue homogenates. b, c Ratios of TGF-β1 protein (b) and mRNA (c) expressions. d, e Ratios of PDGF-B protein (d) and mRNA (e) expression. f, g Ratios of α-SMA protein (f) and mRNA (g) expression. h, i Ratio of α1 type I collagen protein (h) and mRNA (i) expression. Each histogram represents a mean ratio ± SD. *p < 0.05; **p < 0.01; compared with the SP-diet group within each diet-treatment period

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