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Fig. 3 | Environmental Health and Preventive Medicine

Fig. 3

From: Preventive and improvement effects of exercise training and supplement intake in white adipose tissues on obesity and lifestyle-related diseases

Fig. 3

Model of the development of chronic inflammation in WAT. Adipocytes begin to grow as a result of factors such as excess energy intake and lack of exercise, and MCP-1 is secreted from these enlarged cells. Macrophages infiltrate into WAT by the action of MCP-1, and as a result, increased expression of inflammatory adipokines [TNF-α, MCP-1, and interleukin-6 (IL-6)] and decreased expression of anti-inflammatory adipokines (adiponectin) occur in WAT

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