Influence of mitochondrial DNA 5178 C/A polymorphism on serum cholesterol changes: a short-term follow-up in middle-aged Japanese men

Table 4 Total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol among the study subjects in 1999–2000 and 2003–2004 years and changes

Serum cholesterol components^a	1999–2000^b	2003–2004^b	Changes^c
Total group
TC (n = 110)	203.1 ± 35.0	197.1 ± 28.0*	−7.5 (−73 to 64)
LDLC (n = 106)	122.7 ± 31.0	119.9 ± 26.5	−3 (−65 to 70)
HDLC (n = 110)	53.5 ± 11.6	54.2 ± 11.6	1 (−19 to 28)
Mt5178 C group
TC (n = 64)	202.5 ± 36.2	199.0 ± 29.9	−3 (−73 to 64)
LDLC (n = 62)	122.7 ± 32.1	121.6 ± 28.1	−3 (−65 to 70)
HDLC (n = 64)	54.7 ± 11.7	54.0 ± 10.8	0 (−19 to 15)
Mt5178 A group
TC (n = 46)	204.0 ± 33.6	194.5 ± 25.2*	−9.5 (−71 to 45)
LDLC (n = 44)	122.8 ± 29.8	117.5 ± 24.2	−4 (−53 to 53)
HDLC (n = 46)	51.8 ± 11.3	54.5 ± 12.6*	3 (−10 to 28)^#

*p < 0.05, compared to the level of 1999–2000 by Wilcoxon signed-rank test; ^# p < 0.05, compared to the C genotype and A genotype by analysis of covariance adjusted for age, BMI, smoking habit, and drinking habit
^a n refers to the number of patients for which the data were available
^bData are presented as the mean ± SD (units: mg/dl)
^cData are presented as the median, with the minimum–maximum range in parenthesis (units: mg/dl)

ISSN: 1347-4715