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Table 2 Protective effects of E. indica on CCl4-induced alterations in hepatic antioxidant enzymes in rats

From: Eleusine indica L. possesses antioxidant activity and precludes carbon tetrachloride (CCl4)-mediated oxidative hepatic damage in rats

Experimental groups GR (nmol NADPH oxidized/min/mg protein) CAT (nmol H2O2 consumed/min/mg protein) GPX (nmol NADPH oxidized/min/mg protein) Glutathione S-transferase (nmol CDNB conjugate formed/min/mg protein) Quinone reductase (nmol 2,6-DCP reduced/min/mg protein)
Saline control 35.37 ± 0.22 23.97 ± 0.12 46.80 ± 0.44 71.93 ± 0.51 4.81 ± 0.06
CCl4 (1.2 ml/kg b.w.) 14.27 ± 0.44* 7.77 ± 0.20* 19.44 ± 0.40* 35.24 ± 0.20* 2.21 ± 0.08*
E. indica (150 mg/kg b.w.) + CCl4 (1.2 ml/kg b.w.) 16.71 ± 0.09# 8.86 ± 0.13# 23.64 ± 0.15# 38.92 ± 0.17# 2.64 ± 0.02#
E. indica (300 mg/kg b.w.) + CCl4 (1.2 ml/kg b.w.) 22.28 ± 0.19# 14.67 ± 0.26# 31.06 ± 0.28# 45.85 ± 0.39# 3.52 ± 0.03#
  1. Statistical significance: *p < 0.05 compared with saline treated group, # p < 0.05 compared with CCl4 alone treated control (n = 4 animals in each group)
  2. GR Glutathione reductase, CAT catalase, GPX glutathione peroxidase, CDNB 1-chloro-2,4-dinitrobenzene, DCP 2,6-dichloroindophenol, CCl 4 carbon tetrachloride, b.w. body weight
  3. Each value represents the mean ± SE of four animals (n = 4)
  4. Dose regimen, treatment protocols and other details are described in text