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Table 2 Characteristics of subjects according to frequency of drinking alcohol

From: Association between frequency of drinking alcohol and chronic kidney disease in men

 

Nondrinkers (n = 2161)

1–2 days/week (n = 1030)

3–4 days/week (n = 997)

5–6 days/week (n = 1187)

Everyday drinkers (n = 3821)

p-Value

Age (years)A

58.0 ± 5.2

57.5 ± 5.2

57.5 ± 5.0a

57.9 ± 5.3

58.0 ± 5.1c

<0.05

Estimated GFR (mL/min/1.73 m2)A

71.2 ± 12.7

71.5 ± 11.6

72.6 ± 12.1a

73.2 ± 12.9a,b

74.8 ± 12.7a,b,c,d

<0.001

Creatinine (mg/dL)A

0.89 ± 0.28

0.88 ± 0.18

0.87 ± 0.15a

0.87 ± 0.15a

0.84 ± 0.13a,b,c,d

<0.001

BMI (kg/m2)A

23.9 ± 3.1

23.9 ± 2.8

23.9 ± 2.7

23.8 ± 2.7

23.5 ± 2.7a,b,c

<0.001

CRP (mg/L)A

0.14 ± 0.43

0.13 ± 0.41

0.12 ± 0.36

0.13 ± 0.45

0.11 ± 0.36

0.30

HDL-cholesterol (mg/dL)A

56.1 ± 14.2

58.5 ± 14.9a

62.1 ± 15.1a,b

63.1 ± 16.1a,b

65.0 ± 16.6a,b,c,d

<0.001

Hyper-LDL-cholesterolemia (%)B

41.8

38.0

32.8a

31.8a,b

27.0a,b,c,d

<0.001

Hypertension (%)B

30.0

31.4

36.3a

40.7a,b

39.2a,b

<0.001

Diabetes (%)B

13.6

11.7

13.0

13.3

11.9

0.30

Chronic kidney disease (%)B

15.4

12.2

11.9

13.0

9.4a,b,d

<0.001

Medication

 Treatment for cholesterolemia (%)B

11.2

11.3

10.1

9.9

7.5a,b,c,d

<0.001

 Treatment for hypertension (%)B

20.2

20.2

24.1

25.8a,b

25.2a,b

<0.001

 Treatment for diabetes (%)B

7.7

7.2

7.6

6.6

5.3a,c

<0.05

Smoking history (%)B

 Never smokers

35.9

39.4a

35.8

31.7b

21.3a,b,c,d

<0.001

 Former smokers

37.6

41.2

42.1

44.5

44.4

 

 Current smokers

26.5

19.4

22.1

23.8

34.3

 

Regular physical activity (%)B

37.1

38.3

44.1a,b

46.1a,b

35.7c,d

<0.001

  1. Values are mean ± SD
  2. CKD chronic kidney disease, GFR glomerular filtration rate, BMI body mass index, CRP C-reactive protein, HDL high-density lipoprotein, LDL low-density lipoprotein
  3. AAnalysis of variance and post hoc Tukey test
  4. BKruskal–Wallis test and post hoc Bonferroni adjustment
  5. p-Values for analysis of variance or Kruskal–Wallis test. a p < 0.05 compared with nondrinkers, b p < 0.05 compared with 1–2 days/week, c p < 0.05 compared with 3–4 days/week, d p < 0.05 compared with 5–6 days/week by post hoc Tukey test