Development of novel rat model for high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis progression in SHRSP5/Dmcr

Table 3 NAS and fibrosis scores

Diet	Duration (weeks)	Total NAS	Steatosis	Lobular inflammation	Hepatocyte ballooning	Macrovesicular steatosis	Fibrosis stage
Diet	Duration (weeks)	(0–8)	(0–3)	(0–3)	(0–2)	(0–3)	(0–4)
SP	2	1.0 ± 0.38	0.3 ± 0.37	0.8 ± 0.38	0 ± 0.00	0 ± 0.00	0 ± 0.00
SP	8	0.8 ± 0.10	0.2 ± 0.16	0.6 ± 0.14	0 ± 0.00	0 ± 0.00	0 ± 0.00
SP	14	1.0 ± 0.41	0.1 ± 0.12	0.9 ± 0.41	0 ± 0.08	0 ± 0.00	0 ± 0.00
HFC	2	4.9 ± 1.10^a	2.9 ± 0.14^a	1.3 ± 0.53	0.7 ± 1.17	0 ± 0.00	0.3 ± 0.32^a
HFC	8	5.1 ± 0.85^a	3.0 ± 0.00^a	1.3 ± 0.43^a	0.9 ± 0.45^a	1.6 ± 0.64^a,b	2.5 ± 0.79^a,b
HFC	14	5.7 ± 0.86^a	3.0 ± 0.00^a	1.9 ± 0.47^a	0.7 ± 0.51^a	2.0 ± 0.81^a,b	3.0 ± 0.07^a,b

Total NAS indicates the sum of steatosis, lobular inflammation, and hepatocyte ballooning scores. Each figure represents the mean ± SD (n = 6)
^aSignificant differences were observed between the respective SP and HFC diets (p < 0.05)
^bSignificantly different from the respective rats fed each diet for 2 weeks (p < 0.05)

ISSN: 1347-4715