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Table 2 Body and liver weights, blood pressure, and various serum levels in rats fed SP- and HFC-containing diets

From: Development of novel rat model for high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis progression in SHRSP5/Dmcr

 

SP diet

HFC diet

2 weeks

8 weeks

14 weeks

2 weeks

8 weeks

14 weeks

Body weight (g)

263 ± 19

314 ± 20b

327 ± 23b

243 ± 13a

268 ± 14a

277 ± 19a,b

Blood pressure (mmHg)

173 ± 13

175 ± 6.7

180 ± 12

161 ± 14

168 ± 18

136 ± 13a,b,c

Liver weight (g)

7.3 ± 0.72

8.3 ± 0.76

8.7 ± 0.87

11.6 ± 3.8a

34.6 ± 3.8a,b

37.5 ± 4.9a,b

TP (g/dl)

5.8 ± 0.21

6.3 ± 0.17b

6.2 ± 0.25b

6.3 ± 0.12a

6.5 ± 0.24

6.4 ± 0.25

Albumin (g/dl)

4.1 ± 0.08

4.4 ± 0.10

4.2 ± 0.15

4.1 ± 0.12

3.0 ± 0.21a,b

3.1 ± 0.12a,b

Glucose (mg/dl)

132 ± 9.3

158 ± 18b

144 ± 16

111 ± 17a

95 ± 7.4a

100 ± 7.9a

Insulin (ng/ml)

0.52 ± 0.28

1.27 ± 0.68

0.62 ± 0.27

0.75 ± 0.43

0.78 ± 0.34

0.40 ± 0.38

FFA (μEQ/l)

452 ± 64

432 ± 79

477 ± 140

566 ± 174

328 ± 51a

502 ± 384

TG (mg/dl)

36 ± 13

37 ± 9.3

42 ± 7.7

41 ± 5.4

29 ± 11

79 ± 63c

TC (mg/dl)

51 ± 1.6

61 ± 5.2

69 ± 2.8

129 ± 52a

266 ± 157a

1593 ± 884a,b,c

AST (IU/l)

122 ± 12

105 ± 10

118 ± 21

144 ± 11a

545 ± 209a,b

1121 ± 320a,b,c

ALT (IU/l)

47 ± 3.5

52 ± 4.1

50 ± 5.5

94 ± 15a

220 ± 66a,b

387 ± 87a,b,c

Type IV collagen 7S (ng/ml)

3.7 ± 0.36

3.7 ± 0.28

3.5 ± 0.23

3.7 ± 0.22

3.7 ± 0.33

4.7 ± 0.27a,b,c

γ-GTP (IU/l)

1.5 ± 0d

1.5 ± 0d

1.5 ± 0d

1.5 ± 0d

10.3 ± 2.0a,b

13.8 ± 2.9a,b,c

TNF-α (pg/ml)

1.3 ± 1.9

0.5 ± 0.49

2.0 ± 2.0

7.2 ± 1.9a

14.5 ± 3.1a

15.8 ± 6.2a,b

Adiponectin (μg/ml)

5.4 ± 0.44

5.2 ± 1.0

6.3 ± 0.79

7.4 ± 0.95a

4.9 ± 2.3

4.0 ± 0.58a,b

  1. Each figure represents the mean ± SD (n = 6)
  2. aSignificant differences were observed between rats fed SP and HFC diets for the same period (p < 0.05)
  3. bSignificantly different from rats fed the respective diets for 2 weeks (p < 0.05)
  4. cSignificantly different from rats fed the respective diets for 8 weeks (p < 0.05)
  5. dWhen under the limit (3.0 IU/l), the values used were half of the limit