Usefulness of a large automated health records database in pharmacoepidemiology

Table 4 Hazard ratios for cerebrovascular or cardiovascular events

Antihypertensive drug use at registration	Adjusted hazard ratio versus CCB
Antihypertensive drug use at registration	HR (95% CI)	p-Value
CCB	1.00
ARB	0.91 (0.74–1.12)	0.369
Others	1.02 (0.83–1.25)	0.856
2 Drugs use	0.98 (0.83–1.16)	0.814
Over 2 drugs use	1.17 (0.94–1.45)	0.154

Adjusted hazard ratios versus CCB were calculated by Cox regression analysis for the period until the onset of an event, with the following at registration as covariates: gender, age, inpatient/outpatient status at registration, complications (diabetes, hyperlipidemia, cerebrovascular disease, myocardial infarction, angina pectoris, cardiac failure, renal disease, hyperuricemia, and macroangiopathy except cardio-cerebrovascular disease), antihypertensive drugs at registration (CCB, ARBs, other single-use drugs, combination use of two drugs, and combination use of over two drugs), and other medications (antidiabetic drugs, antihyperlipidemic drugs, and antiplatelet or anticoagulant drugs)
CCB calcium channel blocker, ARB angiotensin II receptor blocker

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