Usefulness of a large automated health records database in pharmacoepidemiology

Table 2 Incidence rates for cerebrovascular or cardiovascular event patients

	Number of events (%)	Incidence rate (per 1,000 person-years)
		Present study				Hisayama survey^b		JIKEI-Heart study^c		KYOTO-Heart study^d
		Crude	Standardized^a			Male	Female	ARB	Non-ARB	ARB	Non-ARB
		Crude	Total	Male	Female	Male	Female	ARB	Non-ARB	ARB	Non-ARB
Cardiovascular and cerebrovascular events	1,038 (5.0)	20.08	9.73	10.52	8.98
Cerebrovascular events	869 (4.2)	16.74	8.1	8.28	7.94			6.7	11.1	5.6	10.4
Cerebral hemorrhage	122 (0.6)	2.31	1.27	1.39	1.16	3.0–7.4	0.5–4.6
Cerebral infarction	748 (3.6)	14.38	6.57	6.93	6.22	6.9–8.9	4.6–6.1
Subarachnoid hemorrhage	23 (0.1)	0.43	0.46	0.11	0.79	0.1–0.5	1.0–1.0
Cardiovascular event	192 (0.9)	3.64	1.75	2.41	1.12
Myocardial infarction	192 (0.9)	3.64	1.75	2.41	1.12			3.9	4.4	1.6	2.5

ARB angiotensin II receptor blocker
^aStandardized by age and sex using 2005 census figures
^bIncidence rate of hypertension severity grade I and II in the Hisayama survey
^cCerebrovascular events were defined in the JIKEI-Heart study as stroke or transient ischemic attack
^dCerebrovascular events were defined in the KYOTO-Heart study as stroke

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