Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils

Table 1 Body weight and histopathological changes in the glandular stomach of Mongolian gerbils in the sterigmatocystin (ST)-administered groups

Group	n	Body weight at 99 weeks (g)^a	Active gastritis^b	Erosion events^b	Hyperplastic polyps^b	Intestinal metaplasia^b
Non-treated control	11	106.1 ± 19.5	2/11 (18.2)	1/11 (9.1)	0/11 (0.0)	0/11 (0.0)
ST (100 ppb) administration	7	111.5^c ± 13.0	7/7 (100.0)^d	7/7 (100.0)^d	5/7 (71.4)^d	7/7 (100.0)^e
ST (1,000 ppb) administration	13	86.7 ± 22.0	13/13 (100.0)^d	12/13 (92.3)^d	8/13 (61.5)^d	2/13 (15.4)

^aThe results represent the mean ± SD. The data were analyzed by one-way analysis of variance (ANOVA) followed by Tukey’s multiple comparison test
^bThe results show the number of animals that were histopathologically positive/the number of animals examined (the percentage of positive cases). The data were analyzed by the Chi-square test
^cP < 0.05 compared with the ST (1,000 ppb) administration group
^dP < 0.01 compared with the non-treated control group
^eP < 0.01 compared with the non-treated control and ST (1,000 ppb) administration groups

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