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Table 5 Serum osteocalcin content in rats in the different sodium fluoride-exposure and control groups over time

From: Effect of fluoride exposure on bone metabolism indicators ALP, BALP, and BGP

Group

Fluoride concentration (mg/L)

Number of animals

Content of serum BGP (ng/mL))

Day 0

Day 15

Day 30

Day 90

High-dose

400

4

1.37 ± 0.66

1.31 ± 0.30

0.79 ± 0.27*

0.63 ± 0.11*

Middle-dose

150

4

1.37 ± 0.66

1.08 ± 0.61

1.10 ± 0.10

1.32 ± 0.29* †

Low-dose

10

4

1.37 ± 0.66

1.41 ± 0.64

0.91 ± 0.10

0.72 ± 0.27

Control

0.18

4

1.37 ± 0.66

1.85 ± 0.31

1.20 ± 0.16

0.86 ± 0.10

  1. p < 0.05 compared with the control
  2. † p < 0.05 compared with the low-dose group
  3. Values are given as the mean ± SD
  4. BGP osteocalcin