Effect of the β3-adrenergic receptor gene polymorphism Trp64Arg on BMI reduction associated with an exercise-based intervention program in Japanese middle-aged males

Table 2 Changes in the anthropometric parameters at each time point according to variations in the Trp64Arg β3-adrenergic receptor gene

Parameters/time point	Arg allele non-carrier		Arg allele carrier		p value^a	p value^b	Adjusted R ² ^b
Parameters/time point	Value	Reduction (Δ)	Value	Reduction (Δ)	p value^a	p value^b	Adjusted R ² ^b
Body weight
Baseline	76.1 ± 10.4		73.3 ± 7.2			0.932	0.276
Week 4/Δ4th week	75.3 ± 10.5^c	0.72 ± 1.23	72.6 ± 7.3^c	0.68 ± 1.01	0.892
Week 8/Δ8th week	74.5 ± 10.6^c	1.59 ± 1.94	71.6 ± 7.4^c	1.67 ± 1.72	0.877
Week 12/Δ12th week	74.1 ± 10.6^c	1.98 ± 2.47	70.9 ± 7.5^c	2.40 ± 2.24	0.519
BMI
Baseline	26.6 ± 3.0		25.6 ± 2.3			0.881	0.271
Week 4/Δ4th week	26.3 ± 3.0^c	0.25 ± 0.43	25.4 ± 2.4^c	0.24 ± 0.35	0.954
Week 8/Δ8th week	26.0 ± 3.0^c	0.56 ± 0.68	25.0 ± 2.4^c	0.58 ± 0.61	0.913
Week 12/Δ12th week	25.9 ± 3.0^c	0.70 ± 0.86	24.8 ± 2.5^c	0.84 ± 0.80	0.545
Waist circumference
Baseline	93.4 ± 6.8		91.0 ± 5.5			0.749	0.073
Week 4/Δ4th week	91.7 ± 7.4^c	1.66 ± 1.99	89.9 ± 5.2	1.11 ± 2.61	0.376
Week 8/Δ8th week	91.0 ± 7.3^c	2.34 ± 2.73	89.0 ± 5.6^c	2.02 ± 3.22	0.690
Week 12/Δ12th week	90.3 ± 7.6^c	3.13 ± 2.89	87.9 ± 5.4^c	3.10 ± 3.42	0.968

Data are given as the mean ± SD
^ap value with Student’s t test between Arg allele non-carrier and Arg allele carrier at each point
^bp values were calculated by analysis of covariance adjusting for age, number of steps during intervention, modifications in eating habits during intervention, and observation time
^cp < 0.01 with the paired t test between baseline and each week

ISSN: 1347-4715