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Table 3 Multivariate analyses for the association between history of transfusion or liver disease and cancer mortality: cancer (specific site), all cancer, and nonliver cancer

From: History of blood transfusion before 1990 is associated with increased risk for cancer mortality independently of liver disease: a prospective long-term follow-up study

 

History of transfusion

History of liver disease

n

Adjusted HR (95% CI)

P value

n

Adjusted HR (95% CI)

P value

Cancer (all)

 All

71

1.75 (1.32–2.33)

0.0001

25

1.26 (0.83–1.91)

0.27

 Men

37

1.47 (1.00–2.18)

0.0522

17

1.26 (0.76–2.09)

0.38

 Women

34

2.18 (1.39–3.43)

0.0007

8

1.39 (0.67–2.84)

0.37

Cancer (nonliver)

 All

64

1.68 (1.25–2.26)

0.0007

19

1.00 (0.62–1.61)

0.99

 Men

32

1.33 (0.87–2.02)

0.18

13

1.01 (0.56–1.81)

0.98

 Women

32

2.20 (1.38–3.51)

0.0009

6

1.08 (0.47–2.45)

0.86

Cancer (specific site)

Lung

 All

12

1.54 (0.78–3.06)

0.22

4

1.06 (0.39–2.91)

0.91

 Men

7

1.12 (0.46–2.75)

0.8

3

1.09 (0.34–3.50)

0.88

 Women

5

2.87 (0.90–9.14)

0.07

1

1.31 (0.17–10.18)

0.79

Stomach

 All

13

1.99 (1.01–3.91)

0.0462

4

1.17 (0.42–3.23)

0.76

 Men

7

1.35 (0.55–3.34)

0.51

3

0.78 (0.19–3.22)

0.73

 Women

6

3.24 (0.91–11.52)

0.0698

1

2.32 (0.53–10.11)

0.26

Colorectum

 All

6

1.27 (0.46–3.46)

0.65

1

0.68 (0.09–5.02)

0.71

 Men

1

n/a

n/a

1

2.40 (0.31–18.60)

0.4

 Women

5

1.25 (0.34–4.59)

0.7334

0

n/a

n/a

Liver

 All

7

3.07 (1.14–8.31)

0.0269

6

6.57 (2.51–17.23)

0.0001

 Men

5

3.94 (1.19–13.08)

0.025

4

5.45 (1.65–17.93)

0.0053

 Women

2

2.15 (0.35–11.89)

0.4259

2

9.04 (1.80–45.40)

0.0075

Pancreas

 All

7

3.34 (1.28–8.72)

0.014

0

n/a

n/a

 Men

4

4.10 (1.12–14.98)

0.0328

0

n/a

n/a

 Women

3

2.57 (0.63–10.60)

0.1905

0

n/a

n/a

Other

 All

26

1.47 (0.89–2.42)

0.13

9

1.26 (0.61–2.59)

0.53

 Men

13

1.32 (0.67–2.57)

0.42

6

1.12 (0.45–2.77)

0.81

 Women

13

1.70 (0.80–3.61)

0.16

3

1.58 (0.49–5.13)

0.45

  1. Adjusted HR for cancer mortality was estimated after adjustment for age, sex, and typical risk factors for overall cancer mortality [smoking status (never smokers, current smokers or ex-smokers) and alcohol consumption (never drinkers, current drinkers or ex–drinkers)], history of pregnancy (yes or no), and other factors that may have been related to transfusion or that showed a significant association in the age-adjusted univariate analysis (history of external injury, abdominal surgery, and liver disease). People with history of cancer before participation in the cohort were excluded from this analysis. Each specific site of cancer was defined from ICD, tenth revision, as lung (C34), stomach (C16), colorectum (C18), liver (C22), pancreas (C25)
  2. n/a not applicable