Table 2 Summary of demographic and clinical profiles of cases and controls
Study cohort | Familial participant | Single subject participant | ||||
|---|---|---|---|---|---|---|
Cases | Japanese | Korean | Japanese | Korean | Chinese | Caucasian |
Number of participants | 194 | 5 | 90 | 41 | 23 | 25 |
Age (mean ± SD) | 39.2 ± 20.6 | 23.1 ± 12.8 | 47.7 ± 18.8 | 38.3 ± 13.4 | 25.3 ± 13.3 | 26.4 ± 15.2 |
Female:male | 119:75 | 3:2 | 68:22 | 28:13 | 14:9 | 17:8 |
Number of pedigrees | 36 | 1 | 0 | – | 0 | 0 |
Number of patients | 109 | 2 | – | – | – | – |
Female:male | 76:33 | 1:1 | – | – | – | – |
Family history | – | – | 0 | 3 | 0 | 0 |
Characterization of patients | ||||||
Age of onset (years) | ||||||
<10 | 29 | 1 | 19 | 0 | 7 | 14 |
10–20 | 17 | 0 | 8 | 5 | 6 | 0 |
20–30 | 11 | 0 | 7 | 7 | 4 | 3 |
30–40 | 16 | 1 | 9 | 9 | 3 | 5 |
40–50 | 9 | 0 | 25 | 12 | 3 | 2 |
50–60 | 16 | 0 | 10 | 5 | 0 | 1 |
60+ | 11 | 0 | 8 | 3 | 0 | 0 |
Unknown | 0 | 0 | 4 | 0 | 0 | 0 |
Young onset (<15) | 46 | 1 | 25 | 1 | 10 | 14 |
Adult onset (15≤) | 63 | 1 | 61 | 40 | 13 | 11 |
Clinical symptoms | ||||||
Cerebral infarction | 13 | 0 | 8 | 14 | 3 | 11 |
TIA | 39 | 1 | 33 | 8 | 1 | 2 |
Hemorrhage | 14 | 0 | 19 | 0 | 3 | 1 |
Unknown stroke | 1 | 1 | 1 | 16 | 6 | 3 |
Seizure | 5 | 0 | 1 | 0 | 0 | 2 |
Headache | 9 | 0 | 8 | 2 | 2 | 3 |
Asymptomatic | 23 | 0 | 4 | 0 | 0 | 1 |
Other | 5 | 0 | 16 | 1 | 8 | 2 |
Total | 109 | 2 | 90 | 41 | 23 | 25 |
Clinical symptoms: young onset (<15 years) | ||||||
Cerebral infarction | 4 | 0 | 0 | 0 | 1 | 2 |
TIA | 29 | 1 | 16 | 0 | 1 | 2 |
Hemorrhage | 0 | 0 | 2 | 0 | 0 | 0 |
Unknown stroke | 1 | 0 | 0 | 1 | 2 | 3 |
Seizure | 4 | 0 | 0 | 0 | 0 | 2 |
Headache | 4 | 0 | 5 | 0 | 0 | 3 |
Asymptomatic | 2 | 0 | 0 | 0 | 0 | 1 |
Other | 2 | 0 | 2 | 0 | 6 | 1 |
Total | 46 | 1 | 25 | 1 | 10 | 14 |
Female:male | 28:18 | 0:1 | 22:3 | 1:0 | 6:4 | 9:5 |
Clinical symptoms: adult onset (≥15 years) | ||||||
Cerebral infarction | 9 | 0 | 8 | 14 | 2 | 9 |
TIA | 10 | 0 | 17 | 8 | 0 | 0 |
Hemorrhage | 14 | 0 | 17 | 0 | 3 | 1 |
Unknown stroke | 0 | 1 | 1 | 15 | 4 | 0 |
Seizure | 1 | 0 | 1 | 0 | 0 | 0 |
Headache | 5 | 0 | 3 | 2 | 2 | 0 |
Asymptomatic | 21 | 0 | 4 | 0 | 0 | 0 |
Other | 3 | 0 | 10 | 1 | 2 | 1 |
Total | 63 | 1 | 61 | 40 | 13 | 11 |
Female:male | 48:15 | 1:0 | 43:18 | 27:13 | 8:5 | 8:3 |
Controls | Japanese | Korean | Chinese | Caucasian | ||
|---|---|---|---|---|---|---|
Number of participants | 384 | 223 | 100 | 164 | ||
Age (mean ± SD) | 60.8 ± 9.6 | 40.0 ± 8.4 | 38.2 ± 10.3 | 48.0 ± 19.6 | ||
Female:male | 205:179 | 198:25 | 100:0 | 71:93 | ||
Angiographya | 384 | 46 | 0 | 68 | ||
Screening by angiography (%) | 100.0 | 20.6 | 0 | 41.5 |