Molecular epidemiology of major depressive disorder

Table 2 Major depressive disorder and the 5-HTTLPR polymorphism

Ethnicity	Diagnostic criteria	No. of populations (total no. of subjects)	No. of cases	No. of controls	Frequency (%) among controls^a		OR (95% CI)^a
Ethnicity	Diagnostic criteria	No. of populations (total no. of subjects)	No. of cases	No. of controls	S allele	p*	SS vs. LL	p*	SS vs. LS + LL	p*
All		25 (7,919)	2,934	4,985	47.2 (42.0–52.5)	<0.0001	1.34 (1.14–1.57)	0.34	1.31 (1.17–1.48)	0.83
All	DSM-IV	20 (6,419)	2,368	4,051			1.32 (1.07–1.61)	0.20	1.31 (1.15–1.50)	0.85
Caucasian		21 (7,059)	2,685	4,374	42.5 (40.8–44.2)	0.002	1.34 (1.12–1.61)	0.20	1.34 (1.12–1.52)	0.72
Caucasian	DSM-IV	17 (5,931)	2,239	3,692			1.34 (1.08–1.66)	0.12	1.31 (1.14–1.52)	0.74
Asian		3 (761)	210	551	76.8 (73.9–79.7)	0.27	1.04 (0.51–2.16)	0.78	1.22 (0.87–1.70)	0.69
Asian	DSM-IV	2 (389)	90	299			0.94 (0.35–2.49)	0.53	1.40 (0.84–2.34)	0.63

ISSN: 1347-4715