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Fig. 5 | Environmental Health and Preventive Medicine

Fig. 5

From: Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells

Fig. 5

Schematic model. The combination of isoliquiritigenin and TRAIL markedly induces apoptosis in HT29 cells. Isoliquiritigenin up-regulates DR5 expression, which is considered to enhance TRAIL action. Enhanced TRAIL signaling results in apoptosis through the activation of caspase-8/10, 9 and 3. Caspase-8/10 can activate caspase-3 via caspase-9, which acts downstream of mitochondria

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Environmental Health and Preventive Medicine

ISSN: 1347-4715

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