Hiroshima survivors exposed to very low doses of A-bomb primary radiation showed a high risk for cancers

Watanabe, Tomoyuki; Miyao, Masaru; Honda, Ryumon; Yamada, Yuichi

doi:10.1007/s12199-008-0039-8

Environmental Health and Preventive Medicine

Table 2 The SMR according to colon doses and selected cancers: Okayama, both sexes, aged 0–34 years at time of bomb, 1971–1990

From: Hiroshima survivors exposed to very low doses of A-bomb primary radiation showed a high risk for cancers

Cause of death	Dose categories (Sv)
	<0.005 (very low)				0.005–0.1 (low)				≧0.1 (high)				Total
	O^a	E^b	SMR^c (95% CI)	P value^d	O^a	E^b	SMR^c (95% CI)	P value^d	O^a	E^b	SMR^c (95% CI)	P value^d	O^a	E^b	SMR^c (95% CI)	P value^d
Males
All deaths	682	560.8	1.216 (1.128–1.309)	0.000	715	641.3	1.115 (1.037–1.199)	0.004	403	318.7	1.265 (1.146–1.390)	0.000	1,800	1520.7	1.184 (1.130–1.239)	0.000
All cancers	242	181.5	1.334 (1.179–1.511)	0.000	263	205.9	1.277 (1.132–1.436)	0.000	161	102.9	1.565 (1.340–1.814)	0.000	666	490.3	1.358 (1.260–1.464)	0.000
Leukemia	16	5.1	3.139 (1.981–4.948)	0.000	9	5.9	1.527 (0.799–2.627)	0.283	9	2.9	3.066 (1.598–5.254)	0.001	34	13.9	2.441 (1.741–3.310)	0.000
Solid cancers	218	169.8	1.284 (1.123–1.458)	0.000	250	192.6	1.298 (1.145–1.461)	0.000	147	96.2	1.528 (1.303–1.788)	0.000	615	458.6	1.341 (1.238–1.448)	0.000
Stomach	65	50.7	1.281 (1.001–1.602)	0.045	73	57.6	1.268 (1.002–1.563)	0.042	33	28.8	1.145 (0.812–1.558)	0.492	171	137.1	1.247 (1.075–1.442)	0.004
Colon	12	7.6	1.574 (0.865–2.460)	0.160	12	8.7	1.379 (0.769–2.187)	0.343	9	4.4	2.056 (1.199–3.941)	0.049	33	20.7	1.594 (1.121–2.151)	0.010
Liver	55	23.0	2.395 (1.839–3.063)	0.000	61	26.5	2.305 (1.828–2.970)	0.000	48	13.0	3.702 (2.788–4.808)	0.000	164	62.4	2.629 (2.271–3.065)	0.000
Lung	30	31.0	0.969 (0.679–1.344)	0.932	38	34.7	1.094 (0.792–1.457)	0.637	15	17.5	0.855 (0.508–1.305)	0.625	83	83.2	0.997 (0.807–1.226)	0.979
Females
All deaths	701	610.0	1.149 (1.067–1.236)	0.000	745	687.3	1.084 (1.009–1.164)	0.029	519	382.8	1.356 (1.244–1.474)	0.000	1,965	1680.1	1.170 (1.119–1.222)	0.000
All cancers	244	224.2	1.088 (0.961–1.230)	0.186	286	249.1	1.148 (1.023–1.285)	0.021	241	139.8	1.724 (1.518–1.945)	0.000	771	613.1	1.258 (1.172–1.348)	0.000
Leukemia	6	5.6	1.069 (0.469–1.945)	0.962	6	6.3	0.952 (0.469–1.945)	0.937	12	3.5	3.456 (2.307–6.561)	0.000	24	15.4	1.560 (1.079–2.301)	0.039
Solid cancers	228	211.5	1.078 (0.949–1.225)	0.256	269	234.8	1.146 (1.016–1.285)	0.028	226	131.8	1.714 (1.503–1.942)	0.000	723	578.1	1.251 (1.163–1.344)	0.000
Stomach	43	59.5	0.722 (0.533–0.946)	0.038	56	66.0	0.849 (0.654–1.085)	0.243	57	37.1	1.537 (1.190–1.965)	0.001	156	162.6	0.959 (0.818–1.113)	0.604
Colon	14	14.1	0.994 (0.600–1.588)	0.913	13	15.9	0.818 (0.478–1.310)	0.548	13	8.8	1.473 (0.850–2.329)	0.216	40	38.8	1.031 (0.754–1.367)	0.912
Liver	30	11.3	2.651 (1.915–3.786)	0.000	29	12.5	2.317 (1.557–3.113)	0.000	16	7.1	2.269 (1.415–3.534)	0.001	75	30.9	2.429 (1.932–2.997)	0.000
Lung	21	19.1	1.100 (0.726–1.626)	0.746	38	21.5	1.771 (1.321–2.429)	0.001	27	11.9	2.265 (1.550–3.175)	0.000	86	52.5	1.639 (1.340–2.021)	0.000
Female breast	21	14.3	1.466 (0.985–2.206)	0.103	22	15.5	1.422 (0.972–2.140)	0.125	30	8.8	3.420 (2.340–4.628)	0.000	73	38.6	1.893 (1.490–2.325)	0.000
Uterus	27	15.4	1.755 (1.240–2.540)	0.005	35	17.0	2.061 (1.483–2.795)	0.000	21	9.6	2.177 (1.379–3.089)	0.000	83	42.0	1.975 (1.595–2.423)	0.000

^aObserved number of deaths (person-years)
^bExpected number of deaths (person-years)
^cRisk among Hiroshima survivors in LSS relative to population of Okayama prefecture
^dChi-square test

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