Hiroshima survivors exposed to very low doses of A-bomb primary radiation showed a high risk for cancers

Watanabe, Tomoyuki; Miyao, Masaru; Honda, Ryumon; Yamada, Yuichi

doi:10.1007/s12199-008-0039-8

Environmental Health and Preventive Medicine

Table 1 The standardized mortality ratio (SMR) according to colon doses and selected cancers: Hiroshima, both sexes, age 0–34 years at time of bomb, 1971–1990

From: Hiroshima survivors exposed to very low doses of A-bomb primary radiation showed a high risk for cancers

Cause of death	Dose categories (Sv)
	<0.005 (very low)				0.005–0.1 (low)				≧0.1 (high)				Total
	O^a	E^b	SMR^c (95% CI)	P value^d	O^a	E^b	SMR^c (95% CI)	P value^d	O^a	E^b	SMR^c (95% CI)	P value^d	O^a	E^b	SMR^c (95% CI)	P value^d
Males
All deaths	682	571.5	1.193 (1.107–1.285)	0.000	715	651.5	1.097 (1.020–1.179)	0.013	403	324.1	1.243 (1.128–1.368)	0.000	1,800	1547.1	1.163 (1.111–1.218)	0.000
All cancers	242	195.0	1.241 (1.094–1.402)	0.001	263	220.6	1.192 (1.057–1.341)	0.004	161	110.5	1.456 (1.249–1.690)	0.000	666	526.1	1.266 (1.173–1.364)	0.000
Leukemia	16	5.1	3.150 (1.950–4.871)	0.000	9	5.9	1.538 (0.820–2.694)	0.274	9	2.9	3.069 (1.635–5.376)	0.001	34	13.9	2.453 (1.759–3.343)	0.000
Solid cancers	218	184.6	1.181 (1.035–1.343)	0.014	250	208.6	1.198 (1.059–1.351)	0.004	147	104.6	1.406 (1.196–1.642)	0.000	615	497.7	1.236 (1.142–1.335)	0.000
Stomach	65	55.4	1.174 (0.922–1.476)	0.195	73	62.6	1.167 (0.929–1.449)	0.187	33	31.5	1.049 (0.749–1.436)	0.852	171	149.4	1.145 (0.986–1.323)	0.077
Colon	12	9.0	1.334 (0.769–2.187)	0.404	12	10.3	1.170 (0.675–1.919)	0.698	9	5.1	1.757 (0.936–3.078)	0.136	33	24.4	1.354 (0.966–1.853)	0.100
Liver	55	31.7	1.733 (1.333–2.219)	0.000	61	36.3	1.679 (1.308–2.125)	0.000	48	17.8	2.692 (2.033–3.506)	0.000	164	85.9	1.909 (1.639–2.212)	0.000
Lung	30	29.9	1.005 (0.705–1.395)	0.948	38	33.4	1.138 (0.831–1.527)	0.477	15	16.9	0.886 (0.540–1.387)	0.728	83	80.2	1.035 (0.836–1.269)	0.753
Females
All deaths	701	651.7	1.076 (0.999–1.157)	0.054	745	733.2	1.016 (0.946–1.090)	0.662	519	409.1	1.269 (1.164–1.380)	0.000	1,965	1794.0	1.095 (1.048–1.144)	0.000
All cancers	244	234.8	1.039 (0.917–1.173)	0.550	286	261.1	1.095 (0.976–1.226)	0.124	241	146.6	1.644 (1.449–1.858)	0.000	771	642.6	1.200 (1.118–1.286)	0.000
Leukemia	6	7.0	0.858 (0.402–1.668)	0.851	6	7.8	0.772 (0.362–1.501)	0.648	12	4.4	2.755 (1.589–4.519)	0.001	24	19.1	1.255 (0.846–1.805)	0.317
Solid cancers	228	220.3	1.035 (0.909–1.174)	0.602	269	244.9	1.099 (0.975–1.234)	0.123	226	137.5	1.644 (1.443–1.865)	0.000	723	602.6	1.200 (1.116–1.289)	0.000
Stomach	43	59.9	0.718 (0.534–0.948)	0.034	56	67.1	0.834 (0.643–1.067)	0.175	57	37.6	1.518 (1.173–1.936)	0.002	156	164.6	0.948 (0.811–1.102)	0.505
Colon	14	14.2	0.985 (0.590–1.563)	0.941	13	15.5	0.836 (0.492–1.348)	0.604	13	8.7	1.487 (0.876–2.398)	0.204	40	38.5	1.039 (0.764–1.385)	0.873
Liver	30	15.9	1.889 (1.326–2.622)	0.001	29	17.5	1.656 (1.156–2.311)	0.009	16	9.9	1.615 (0.999–2.507)	0.076	75	43.3	1.733 (1.384–2.147)	0.000
Lung	21	21.0	1.002 (0.658–1.474)	0.920	38	23.8	1.599 (1.167–2.146)	0.005	27	13.2	2.039 (1.405–2.878)	0.000	86	58.0	1.484 (1.202–1.813)	0.000
Female breast	21	17.0	1.235 (0.811–1.816)	0.397	22	18.5	1.189 (0.788–1.736)	0.485	30	10.4	2.876 (2.019–3.993)	0.000	73	45.9	1.589 (1.265–1.974)	0.000
Uterus	27	15.3	1.767 (1.218–2.493)	0.004	35	16.8	2.087 (1.503–2.833)	0.000	21	9.5	2.204 (1.447–3.241)	0.000	83	41.6	1.996 (1.611–2.448)	0.000

^aObserved number of deaths (person-years)
^bExpected number of deaths (person-years)
^cRisk among Hiroshima survivors in the life span study (LSS) relative to population of Hiroshima prefecture
^dChi-square test

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