Factors associated with serum total homocysteine level in type 2 diabetes

Table 3 Correlations with serum total homocysteine concentration level in diabetics and non-diabetic subjects according to multiple regression analysis

	DM (n = 196)				Non-DM (n = 391)
	Partial regression coefficient (β) ± SE (Model A^d)	Standardized partial regression coefficient (Model A^d)	p value (Model A^d)	Standardized partial regression coefficient (Model B^e)	Partial regression coefficient (β) ± SE (Model A^d)	Standardized partial regression coefficient (Model A^d)	p value (Model A^d)	Standardized partial regression coefficient (Model B^e)
Males
Age	0.017 ± 0.051	0.023	0.746	−0.036	−0.001 ± 0.014	−0.004	0.939	−0.102
FPG	0.020 ± 0.006	0.227	0.001	–	0.026 ± 0.021	0.064	0.226	–
HbA1c	0.654 ± 0.347	0.132	0.061	0.118	0.107 ± 0.542	0.011	0.843	−0.042
TC	0.048 ± 0.014	0.231	0.001	−0.040	0.010 ± 0.004	0.124	0.020	0.101
logTG	1.948 ± 0.843	0.163	0.022	0.018	−0.033 ± 0.321	−0.006	0.917	−0.074
Cre	6.988 ± 1.998	0.250	<0.001	–	3.948 ± 1.243	0.167	0.002	–
eGFR	−0.109 ± 0.033	−0.251	0.001	−0.468**	−0.039 ± 0.013	−0.160	0.004	−0.161*
BP	0.705 ± 0.678	0.077	0.299	−0.052	0.420 ± 0.204	0.116	0.040	0.046
a-h agent	2.184 ± 1.166	0.143	0.063	0.257*	0.859 ± 0.428	0.111	0.046	0.099
BMI	0.039 ± 0.059	0.043	0.513	0.014	0.116 ± 0.065	0.097	0.073	0.106
Smoking^a	2.136 ± 1.131	0.134	0.060	0.052	0.477 ± 0.471	0.054	0.311	0.047
Drinking^b	0.588 ± 1.087	0.038	0.590	−0.048	−0.806 ± 0.403	−0.104	0.046	−0.157*
V event^c	−1.230 ± 1.347	−0.067	0.363	−0.154*	−0.002 ± 0.577	−0.001	0.997	−0.021

Cre, Serum creatinine; eGFR, estimated glomerular filtration rate by MDRD method; BP, blood pressure (N = 0; normal as SBP < 130 mmHg, and DBP < 80 mmHg, B = 1; high level of normal range as 130 mmHg ≤ SBP < 140 mmHg, and/or 80 mmHg ≤ DBP < 90 mmHg except for hypertension, H = 2; hypertension as SBP ≥ 140 mmHg, or DBP ≥ 90 mmHg); a-h agent, anti-hypertensive agent (no = 0, routine intake = 1)
^aSmoking habits; non-smokers = 0, current smokers = 1
^bDrinking habits; non-or occasional drinkers = 0, habitual drinkers = 1
^cVascular event; history of Myocardial infarction or Cerebral Infarction (not yet = 0, or have past history = 1)
^dModel A was adjusted for age and Cre, however, that of eGFR was adjusted for Age
^eModel B was adjusted for multi-variables (Age, HbA1c, TC, logTG, eGFR, BP, a-h agent, BMI, Smoking, Drinking and V event)
* p value < 0.05, ** p value < 0.001

ISSN: 1347-4715