Fig. 1

Products of the Erc/mesothelin gene and the enzyme-linked immunosorbent assay (ELISA) system. The primary product of the Erc/mesothelin gene is a 71-kDa precursor protein. This protein is physiologically cleaved, releasing its 31-kDa N-terminal fragment into the blood. The authors’ system detects 31-kDa N-terminal fragments using a sandwich ELISA containing two antibodies against N-terminal fragments [8]