Applications of CYP-450 expression for biomonitoring in environmental health

Lee, Ho-Sun; Yang, Mihi

doi:10.1007/s12199-007-0009-6

Environmental Health and Preventive Medicine

Table 1 Alterations in cytochrome P450s (CYPs) due to exposure to xenobiotics

From: Applications of CYP-450 expression for biomonitoring in environmental health

Xenobiotics	Exposure biomarker^a	CYPs	Associations^b	Biospecimens^a	References
Polycyclic aromatic hydrocarbons (PAHs)	BaP-DNA adducts	CYP1A1- and CYP1B1* – total RNA	↑	NHMECs	Keshava et al. [89]
		CYP1A2 activity	-	Human lymphocytes	Funck-Brentano et al. [22]
	BPDE-DNA adducts	CYP1A1 activity**	↑	Human lung tissue	Alexandrov et al. [28]
	3-NBA-DNA adducts	CYP3A4** and CYP1A1 activity	↑ and -, respectively	V79 cell lines	Bieler et al. [35]
		CYP2C9 activity**	↑	Human B-lymphoblastoid MCL-5	Arlt et al. [33]
	3-ABA-DNA adducts	CYP1A1, CYP1A2 activity	↑	Human B-lymphoblastoid MCL-5	Arlt et al. [34]
	4-ABP-Hb adducts	CYP1A2 activity**	↑	Human Peripheral blood	Sarkar et al. [73]
		CYP1A2 activity	↑	Urine	Landi et al. [75]
	Bulky-DNA-adducts	CYP1A1 mRNA	↓	Human placenta tissue	Whyatt et al. [27]
		CYP1A1, CYP2C and CYP3A4 activity**	All ↑	Human larynx tissue	Kap-Soon et al. [10]
		CYP1B1 and CYP3** protein	- and ↑, respectively	Human BAL sample	Piipari et al. [30]
		CYP1A1 total RNA**	↑	Human lung tissue in NSCLC	Mollerup et al. [29]
	AhR/ ARNT	CYP1B1 total RNA**	↑	Human lymphocytes	Lin et al. [18]
		CYP1A2 protein	↑	LS180 cell lines	Li et al. [20]
	AhR	CYP1B1 mRNA	↑	MOG-G-CCM cells	McFadyen et al. [16]
		CYP1A1 and 1B1 protein	All ↑	Lung tissues in adenocarcinoma	Chang et al. [17]
		CYP1A1** mRNA	↑	Human pheripheral blood	Hayashi et al. [19]
	1-OHP	CYP1B1 mRNA	↑	Human pheripheral blood	Hanaoka et al. [90]
		CYP1A1, CYP1B1, CYP1A2 activity	all ↑	BTI-TN-5B1-4 cells	Kim et al. [21]
		CYP1A2 activity**	↑	Human lymphocyte	Funck-Brentano et al. [22]
	CAs	CYP2E1 mRNA*	↑	Human peripheral blood	Vodicka et al. [44]
	8-OHdG	CYP1A1 activity	↑	Hepa1c1c7 cell	Park et al. [91]
		CYP1A2 activity**	↑	Urine	Loft et al. [36], Poulsen et al. [40]
	1-naphthol and dihydrodiol	CYP1A2 activity	↑	BTI-TN-5B1-4 cells	Cho et al. [25]
	2-NT	CYP3A4 activity	↑	BTI-TN-5B1-4 cells	Cho et al. [25]
		CYP2E1 mRNA**	↑	Human blood sample	Nan et al. [92]
Benzene	Total hydroxylated benzene metabolites	CYP2E1 and CYP2F1 activity**	All ↑	Human BEAS-2B cells and Human A549 cells	Sheets et al. [52]
		CYP2E1 activity**	↑	Human liver sample	Nedelcheva et al. [49]
	2-nitrophenol	CYP2E1 activity**	All ↑	Human hepatic micromosome	Miksanova et al. [93]
Toluene	HA	CYP2E1 mRNA**	↑	Human lymphocytes and urine	Mendoza-Cantu et al. [58]
Toluene	Toluene metabolites	CYP2E1 and CYP1A2 activity**	↑	Human liver microsomes	Tassaneeyakul et al. [53]
Heterocyclic amines (HCAs)	Urinary unconjugated MeIQx	CYP1A2 activity**	↑	Urine	Sinha et al. [77]
	PhIP metabolites	CYP1A1 activity	↑	Sf9 insect cells	Crofts et al. [94]
	HONH-PhIP	CYP1A2 activity	↑	Human liver sample	Langouet et al. [95]
Tobacco	Cotinine	CYP2A6 content**	↑	Human B-lymphoblastoid cells	Nakajima et al. [84]
		CYP2E1** activity	↓	Human microsomes	Van Vleet et al. [96]
		CYP1B1 mRNA**	↑	Human peripheral blood	Hanaoka et al. [90]
		CYP1A2 activity**	↑	Human lymphocyte and urine	Funck-Brentano et al. [22]
Nitro-samines	Induced revertants	CYP1A1, 2A6 and 2E1 activity	All ↑	S. typhimurium YG7108 cells	Fujita and Kamataki [87, 88], Smith et al. [97], Kushida et al. [98]
Nitro-samines	NNK and NNAL metabolites	CYP3A4 activity**	↑	Human hepatic microsomes	Staretz et al. [99]

*Borderline significant, 0.05 < P < 0.1; **significant, P < 0.05
^aNHMEC, normal human mammary epithelial cell; V79, Chinese hamster cell line; LS-180, human colon adenoma cell line; NSCLC, nonsmall cell lung cancer; BTI-TN-5B1-4, haculovirous-infected insect (Autographa californica) cell; Sf9, insect cell; BEAS-2B, bronchiolar derived human cell line; MOG-G-CCM, human cell line; AaC, 2-amino-9H-pyrido[2,3-b]indole; HONH-PhIP, 2-(hydroxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine
^b↑, Positive association; ↓, negative association; −, no association

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