Fig. 1
From: Epigenetic abnormalities in cardiac hypertrophy and heart failure
Epigenetic changes at different levels of chromatin structure. CpG sites within genomic DNA undergo methylation, and core histones in nucleosomes undergo acetylation (Ac), methylation (Met), ubiquitination (Ub), sumoylation (S), or phosphorylation (P). Higher order chromatin structure is also dynamically modified by chromatin-remodeling complexes