DNA methylation: a marker for carcinogen exposure and cancer risk

Table 1 Reports on epigenetic field for cancerization (modified from [53]

Cancer	Inducing factor	Analyzed gene	References
Liver	HBV and/or HCV	CDKN2A,hMLH1,THBS-1 and five MINT loci	Kondo et al. [41]
Colorectal cancer
Sporadic	Unknown	MGMT	Shen et al. [44]
UC associated	UC	CDKN2A	Hsieh et al. [40]
UC associated	UC	ER, MYOD, CDKN2A, and CSPG2	Issa et al. [52]
Barrett’s cancer	Barrett’s esophagus	APC,CDKN2A, and ESR1	Eads et al. [48]
Lung cancer	Smoking?	CDKN2A, MGMT, DAPK, SOCS1, RASSF1A, COX2, and RARβ	Guo et al. [49]
Gastric cancer	H. pylori	CDKN2A,LOX,THBD, HRASLS,FLNc,HAND1, and p41ARC	Maekita et al. [22]
Breast cancer	Unknown	CYP26A1	Yan et al. [45]
Renal cancer	Unknown	CDKN2A, hMLH1,THBS-1, and five MINT loci	Arai et al. [47]

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